Unveiling ac4C modification pattern: a prospective target for improving the response to immunotherapeutic strategies in melanoma

Abstract Emerging evidence has confirmed the inextricable connection between N4-acetylcytidine (ac4C) mRNA modification and the clinical characteristics of malignancies.Nonetheless, it is uncertain whether and how ac4C mRNA modification patterns affect clinical outcomes in melanoma patients.This research integrated single-cell sequencing data and t

read more


Early vascular healing after neXt-generation drug-eluting stent implantation in Patients with non-ST Elevation acute Coronary syndrome based on optical coherence Tomography guidance and evaluation (EXPECT): study protocol for a randomized controlled trial

BackgroundThere is limited evidence about vessel wall healing response following implantation of next-generation drug-eluting stents (DES) in patients admitted with a non-ST elevation acute coronary syndrome (NSTE-ACS).Cumulative data indicate that optical coherence tomography (OCT) imaging can optimize percutaneous coronary intervention results an

read more